The role of the endocannabinoid system (ECS) in the regulation of endocrine function and in the control of energy balance in humans…
CBD (Cannabidiol) is a chemical compound that comes from the hemp plant. It is one of over 85 unique compounds found in hemp, known as cannabinoids. Cannabinoids, which can be either consumed (phytocannabinoids) or produced naturally by the body (endocannabinoid), are chemical compounds that interact with the body’s ECS (Endocannabinoid System} which all mammals also have. This system is known to manage homeostasis in the human body and affect bodily processes such as a modulatory system in the function of brain, secretion of hormones related to reproductive functions and response to stress endocrine, . CBD is an example of a phytocannabinoid. Although our bodies can naturally produce its own endocannabinoids that bind to cannabinoid receptors in both the central nervous system and the peripheral nervous system, phytocannabinoids are known to help to kickstart our central regulatory system.
In humans this system also controls energy homeostasis and mainly influences the function of the food intake centers of the central nervous system and gastrointestinal tract activity. The endocannabinoid system regulates not only the central and peripheral mechanisms of food intake, but also lipids synthesis and turnover in the liver and adipose tissue as well as glucose metabolism in muscle cells. Rimonabant, a new and selective central and peripheral cannabinoid-1 receptor (CB1) blocker, has been shown to reduce body weight and improve cardiovascular risk factor (metabolic syndrome) in obese patients by increasing HDL-cholesterol and adiponectin blood levels as well as decreasing LDL-cholesterol, leptin, and C-reactive protein (a proinflammatory marker) concentrations.
It is therefore possible to speculate about a future clinical use of CB1 antagonists, as a means of improving gonadotrophin pulsatility and fertilization capacity as well as the prevention of cardiovascular disease and type 2 diabetes mellitus. Drugs acting as agonists of CB1 receptors (Dronabinol, Dexanabinol) are currently proposed for evaluation as drugs to treat neurodegenerative disorders (Alzheimer’s and Parkinson’s diseases), epilepsy, anxiety, and stroke.
Even with the wave of states legalizing medical marijuana, many physicians are still reluctant to even prescribe the CBD cannabinoid because they are not sure what dosages to prescribe. After all, most medical schools never cover CBD Cannabidiol in their pharmacology courses. Medical scientists are just now developing dosing schedules for medical marijuana, medicinal hemp and their extracts, including CBD.
CBD-rich hemp oil comes in various concentrations and forms, including liquid hemp oil, hemp oil as a thick paste, oil in capsules, sublingual tincture drops or sprays, salves for topical use, edibles as in candy or gum and CBD vapor from vaporizers similar to e-cigarettes.