Dosage Guidelines, Use of Cannabidiol (CBD), Safety & Potential Side Effects

Cannabidiol, better know as CBD, has no known adverse side effects at any dose, but some drug interactions can be problematic. An excessive amount of CBD could be less effective therapeutically than a moderate dose. “Less is more” is often the case with respect to Hemp CBD therapy.

“Dosage is everything”—Paracelsus

The role of the endocannabinoid system (ECS) in the regulation of endocrine function and in the control of energy balance in humans…

CBD (Cannabidiol) is a chemical compound that comes from the hemp plant. It is one of over 85 unique compounds found in hemp, known as cannabinoids.  Cannabinoids, which can be either consumed (phytocannabinoids) or produced naturally by the body (endocannabinoid), are chemical compounds that interact with the body’s ECS (Endocannabinoid System} which all mammals also have. This system is known to manage homeostasis in the human body and affect bodily processes such as a modulatory system in the function of brain, secretion of hormones related to reproductive functions and response to stress endocrine, .  CBD is an example of a phytocannabinoid. Although our bodies can naturally produce its own endocannabinoids that bind to cannabinoid receptors in both the central nervous system and the peripheral nervous system, phytocannabinoids are known to help to kickstart our central regulatory system.

In humans this system also controls energy homeostasis and mainly influences the function of the food intake centers of the central nervous system and gastrointestinal tract activity. The endocannabinoid system regulates not only the central and peripheral mechanisms of food intake, but also lipids synthesis and turnover in the liver and adipose tissue as well as glucose metabolism in muscle cells. Rimonabant, a new and selective central and peripheral cannabinoid-1 receptor (CB1) blocker, has been shown to reduce body weight and improve cardiovascular risk factor (metabolic syndrome) in obese patients by increasing HDL-cholesterol and adiponectin blood levels as well as decreasing LDL-cholesterol, leptin, and C-reactive protein (a proinflammatory marker) concentrations.

It is therefore possible to speculate about a future clinical use of CB1 antagonists, as a means of improving gonadotrophin pulsatility and fertilization capacity as well as the prevention of cardiovascular disease and type 2 diabetes mellitus. Drugs acting as agonists of CB1 receptors (Dronabinol, Dexanabinol) are currently proposed for evaluation as drugs to treat neurodegenerative disorders (Alzheimer’s and Parkinson’s diseases), epilepsy, anxiety, and stroke.

Even with the wave of states legalizing medical marijuana, many physicians are still reluctant to even prescribe the CBD cannabinoid because they are not sure what dosages to prescribe. After all, most medical schools never cover CBD Cannabidiol in their pharmacology courses. Medical scientists are just now developing dosing schedules for medical marijuana, medicinal hemp and their extracts, including CBD.

CBD-rich hemp oil comes in various concentrations and forms, including liquid hemp oil, hemp oil as a thick paste, oil in capsules, sublingual tincture drops or sprays, salves for topical use, edibles as in candy or gum and CBD vapor from vaporizers similar to e-cigarettes.

Everyone Is Different

What you will find on this page is meant to be a guideline, a starting point of reference. The fact remains that everyone is in a different place and will react differently to their CBD dosage. As serving size or dosage of CBD differs for each person, it is best to start small and gradually increase until you experience the desired result.

CBD Brands Confusing Dosage

CBD oil brands create a lot of confusion for consumers because they all have different standards. Many of them recommend way too much as a “serving” and others recommend too little. Because of this lack of standard during our review of individual CBD products, a COR Serving Standard was created to make things simple.

CBD Oil Dosing

Concentrations vary between preparations, ranging from 1 mg per dose to hundreds of milligrams. This makes it easy for consumers to get the dosages they need in a form they find easy to use.

CBD Dosages

Mayo Clinic suggests CBD dosages on scientific research, publications, traditional use, or expert opinion. Cannabinoid dosages and duration of treatment depend largely on the disease.

Disclosure: The following statements are not necessarily those of Hemp & Heal LLC, any of it’s vendors, employees or affiliates. These statements were gathered from reliable sources on the internet and may not be those of the FDA or any other federal government agency. Use with your own risk and like ALWAYS SEEK YOUR MEDICAL PHYSICIANS ADVICE FOR ANY UNANSWERED QUESTIONS ON TAKING CANNABIDIOL (CBD) HEMP OIL PRODUCTS.

First Decide how you want to take your CBD

Hemp & Heals Industrial Hemp Sativa L oil products are available in tincture dropper bottles, sprays, soft gel & dry capsules, edibles, vaping and other products.  You can see and read more about each of our products in more detailed information directly of our website at www.hempandheal.com under the tab “Products”

Find Your Ratio

Hemp derived CBD oil products have varying amounts of CBD and low 0.3 or less of THC. A high CBD or high even a high THC product is not necessarily superior in combination to optimize your therapeutic use of Hemp derived CBD products. We at Hemp & Heal provide the best US grown hemp under the DOA pilot program using only Hemp derived CBD turned into a pure Isolate and full spectrum hemp oil of all cannabinoids, terpenes, flavonoids and over 400 trace elements found in the farms Industrial Hemp, Sativa L Strain for maximum health benefits as to create the magic that hemp causes called “The Entourage Effect”.

  • Begin with a low dose. Especially if you have little or no experience with hemp derived CBD oil products.
  • Take a few small doses. Over the course of the day rather than one big dose. Best is on an empty stomach when you first wake up or in between meals.
  • Use the same dose and ratio for several days. Observe the effects and if necessary adjust the ratio or amount.
  • Possible side effects. Multiple studies, published as early as 1980, suggest that CBD has minimal side effects and is overall safe for consumption.
  • Consult your health counselor if your still unsure of using Hemp derived CBD oil. Proceed cautiously, especially if you have a history of alcohol or drug abuse, mental illness, or are pregnant or breastfeeding.

How Much CBD Oil Should I Take?

Serving Standard is 25mg of CBD taken twice a day. It is also recommended that you try increasing dosage every 3-4 weeks by 25mg until symptom relief. And to decrease amount of CBD with any worsening of symptoms.

To increase appetite in cancer patients: 1 mg of CBD or more for six weeks

To treat chronic pain: 2.5-20 mg or more of CBD by mouth for an average of 25 days

To treat epilepsy: 200-300 mg of CBD by mouth daily for up to 4.5 months

To treat movement problems associated with Huntington’s disease: 10 mg per kilogram of CBD by mouth daily for six weeks

To treat sleep disorders: 40-160 mg CBD by mouth.

To treat multiple sclerosis symptoms: 2.5 milligrams of CBD at doses of 2.5-120 milligram for up to eight weeks. Patients typically use eight sprays within any three hours, with a maximum of 48 sprays in any 24-hour period.

To treat schizophrenia: 40-1,280 mg CBD by mouth daily for up to four weeks

To treat glaucoma: a single CBD dose of 20-40 mg under the tongue. Doses greater than 40 mg may actually increase eye pressure.

According to CannLabs, the nation’s top full-service testing lab for cannabis products, there is no established lethal CBD dose. Consumers should read product inserts carefully to ensure they are taking the right amount of CBD, and talk to the prescribing physician about any questions or concerns.

How to Use CBD Oil – How to Take CBD Oil

CBD is most commonly taken orally in a concentrated paste or drops/ tincture format. To take CBD oil first hold it under the tongue to be absorbed in the mouth prior to swallowing. This step is important because some of the CBD taken will be broken down by the digestive system. Other oral methods include capsules, mouth strips, and edibles such as chocolate bars. Many people also enjoy using CBD oil via vaporizers or inhalers as this is a near instant delivery method that can be quite effective. Others use CBD oil by taking it through the skin via lotions, balms, creams or patches. There are many ways to take CBD oil, what matters most is trying a few different approaches and seeing what works. Again, everyone is different.

If you are already purchasing CBD product you could be overpaying for inferior products that just won’t deliver the CBD dosage you need. That’s why we constantly focus on the products that use the latest in technology as well as CBD absorption

What Are The Side Effects Of CBD?

Cannabidiol (CBD) is one of over 80 naturally occurring cannabinoids found in a cannabis plant. Unlike Tethrahydocannabdiol (THC), known for its psychoactive elements, CBD is non-intoxicating and can offer relief and benefits without the disconcerting feelings of lethargy or dysphoria. The majority of information on the Internet today, highlights the potential benefits of CBD, but are there known side effects that users should be aware of and is there a limit to how much CBD one person can safely consume?

Safety & the Potential Side Effects of Cannabidiol (CBD)

Multiple studies, published as early as 1980, suggest that CBD has minimal side effects and is overall safe for consumption. Nonetheless, consumers should be made aware of any known, potential drawbacks of something you are putting in your body. Below, we discuss the findings from each recorded study and review on the safety and known side effects of CBD.

1980 Study in Pharmacology

On January 3, 1980, Pharmacology published their findings conducted during a study in which they tested eight healthy volunteers and 15 patients with epilepsy, looking at the side effects of CBD when consumed daily for a month. Their reported conclusions were, ‘All patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination.’

– International Journal of Neuroscience

1986 Study

In 1986, oral doses, ranging from 100 to 600 mg per day of cannabidiol were given to 5 patients with dystonic movement disorders. In addition to recording specific benefits, this study also uncovered mild side effects of CBD such as hypotension, dry mouth, psychomotor slowing, lightheadedness, and sedation. It is also noteworthy, that during this study 2 patients given CBD in doses over 300 mg per day seemed to aggravate their Parkinson’s symptoms. Yet in 2014 a separate paper described how CBD significantly improves the lives of those with Parkinson’s disease.

2006 Argentinian Study

In 2006 a group of scientists hypothesized that there are cannabinoid receptors in human salivary glands. In fact, their hypothesis was correct, which is most likely the reason that one of the previously discovered side effects of CBD is what’s commonly known as cottonmouth. When CBD interacts with the endocannabinoid system (ECS), it inhibits the secretion of saliva, thus leaving some users with a dry sensation in their mouth.

2011 Study

A review on the safety and side effects of cannabidiol, found that CBD might interfere with the hepatic drug metabolism, alteration of in vitro cell viability, decreased fertilization capacity or the reduced activity of p-glycoprotein. Has a pharmacist or doctor ever told you not to drink or eat grapefruit while taking a prescription medication? Grapefruit and CBD have a similar effect on P450, an enzyme found in the liver, which metabolizes different kinds of drugs in the human body. If taken in large doses, CBD can inhibit the metabolizing properties of P450, temporarily neutralizing the effects of other medicinal products in the body’s system. This side effect is also responsible for why cannabidiol counteracts the effects of THC.

Can you overdose on CBD?

Cannabidiol and other cannabinoids are known to be non-toxic, with no known fatal overdose levels ever reported. The previously mentioned study from 2011 indicated that chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. The Department of Health and Human Services states, ‘no signs of toxicity or serious side effects have been observed following chronic administration of cannabidiol to healthy volunteers (Cunha et al., Pharmacology 21:127-185, 1980), even in large acute doses of 700 mg/day (Consroe et al., Pharmacol, Biochem, Behav. 40:701-708, 1991).’

As you can see, there is evidence that supports CBD being a safe substance with minor side effects.